Two mysterious women seek refuge in a run-down coastal resort. Clara meets lonely Noel, who provides shelter in his deserted guesthouse, Byzantium. Schoolgirl Eleanor befriends Frank and tells him their lethal secret. They were born 200 years ago and survive on human blood. As knowledge of their secret spreads, their past catches up on them with deathly consequence.

Two faiths, two empires, two rulers - colliding in 1588. Papist Spain wants to bring down the heretic Elizabeth. Philip is building an armada but needs a rationale to attack. With covert intrigue, Spain sets a trap for the Queen and her principal secretary, Walsingham, using as a pawn Elizabeth's cousin Mary Stuart, who's under house arrest in the North. The trap springs, and the armada sets sail, to rendezvous with French ground forces and to attack. During these months, the Virgin Queen falls...